CoQ10 - Health for the Heart

What is very essential to be said about Coenzyme Q10, is that it is actually oil-soluble, vitamin-like substance which is present in most cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. 95% (percent) of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney—have the highest CoQ10 concentrations.

Discovery and history
Coenzyme Q10 was first discovered by Professor Fredrick L. Crane and colleagues at the University of Wisconsin–Madison Enzyme Institute in 1957. In 1961 Peter Mitchell proposed the electron transport chain (which includes the vital protonmotive role of CoQ10) and he received a Nobel prize for the same in 1978 ... read more

Biochemical role
CoQ10 is found in the membranes of many organelles. Since its primary function in cells is in generating energy, the highest concentration is found on the inner membrane of the mitochondrion. 

Antioxidant function of CoQ10
The antioxidant nature of CoQ10 derives from its energy carrier function. As an energy carrier, the CoQ10 molecule is continually going through an oxidation-reduction cycle. As it accepts electrons, it becomes reduced. As it gives up electrons, it becomes oxidized. In its reduced form, the CoQ10 molecule ... read more


Absorption
CoQ10 is a crystalline powder that is insoluble in water. Absorption follows the same process as that of lipids and the uptake mechanism appears to be similar to that of vitamin E, another lipid-soluble nutrient. This process in the human body ... read more

Metabolism
It appears that CoQ10 is metabolised in all tissues, while a major route for its elimination is biliary and fecal excretion. After the withdrawal of CoQ10 supplementation, the levels return to normal within a few days, irrespective of the type of formulation used.This is the mein reason why AquaSource advises people to take supporting the heart function CoQ10 within 3-4 months during the year, or every 3-d or 4-th monht in order to supply additional strength to the muscle.

Supplementation benefits
According to the Mayo Clinic, "CoQ10 has been used, recommended, or studied for numerous conditions, but remains controversial as a treatment in many areas." Coenzyme Q10, in its reduced form as solubilized ubiquinol, is approved for use as an orphan product in the treatment of Huntington's disease and pediatric congestive heart failure.


Heart health
The most imporatnt role of the hart is the correct circulation of the blood in our body. The blood stream, which heart regulates, is the  main fluid throughout our body to feed every organ and the whole organism of billions of cells.

Coenzyme Q10 helps maintain a healthy cardiovascular system.There is evidence ... read more




Blood pressure
There are several reports concerning the effect of CoQ10 on blood pressure in human studies. A recent (2007) meta-analysis of the clinical trials of CoQ10 for hypertension assessed overall efficacy, consistency of therapeutic action, and side-effect incidence. Meta-analysis was performed in 12 clinical trials (362 patients). The meta-analysis concluded that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure and diastolic blood pressure  without significant side-effects.


Cardiac arrest, Migraine headaches
... read more

Supplementation of coenzyme Q10 has been found to have a beneficial effect ... read more


Cancer
CoQ10 is also being investigated as a treatment for cancer, and as relief from cancer treatment side-effects.

Lifespan
One study demonstrated that low dosages of coenzyme Q10 reduce oxidation  and a combination of a diet rich in polyunsaturated fatty acids and coenzyme Q10 supplementation leads to a longer lifespan. 

What should we eat to absorb more Coenzyme Q10 in our blood and organs? ... read more


Intake
In the developed world, the estimated daily intake of  CoQ10 has been determined at 3–6 mg per day, derived primarily from meat.